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KMID : 0604520060320030193
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 3 p.193 ~ p.200
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Moisturizing and Anti-oxidation Effect of Astragalus membranaceus Root Extract
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Jung Taek-Kyu
Kim Mi-Jin
Lim Kyung-Ran
Yoon Kyung-Sup
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Abstract
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We investigated the effect of moisturizing and anti-oxidation of Astragalus membranaceus (Astragali Radix) root extract with respective to growing districts and extract methods for the purpose of development of cosmetic ingredients. Astragalii Radix was collected in Jecheon, Jeongseon, Taebaek, and Yeongju in Korea and China as growing districts. Formononetin was determinated by HPLC method as one of the various active agents in Astragalus membranaceus root extract. The 75% ethanol extract demonstrated to be more effective than H_2O-extracted one for a scavenging activities to DPPH radicals and reactive oxygens. The 75% ethanol extract showed IC_{50} (50% scavenging concentration) of 2.162 mg/mL and 2.981 mg/mL in case of free radical scavenging activity test and reactive oxygen scavenging activity test, respectively Especially, free radical scavenging activity of isoflavonoids isolated from ethylacetate fraction was similar to scavenging activity of genistein. Astragalus membranaceus root extract of Jecheon district by sonicating extraction method was more effective in skin hydration compared with others.
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KEYWORD
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Astragalus membranaceus, formononetin, moisturizing, anti-oxidation, free radical scavenging activity, reactive oxygen scavenging activity
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